The latest feature illustration is one Audra recently created featuring the release of neurotransmitter, GABA, (y-aminobutyric acid) molecules from presynaptic vesicles into the synaptic gap. GABA is shown binding to the GABAa receptor pentamer in the postsynaptic membrane, resulting in the opening of the receptor channel. Negatively charged chloride ions flow through the open channel into the postsynaptic neuron causing a hyperpolarization of the postsynaptic bulb. This has as an inhibitory effect on neural transmission by preventing the development of an action potential.
The GABARAP molecule, the hexagonal lattice formed by gephyrin molecules and cytoskeletal tubulin dimers are depicted beneath the postsynaptic membrane. They form part of the postsynaptic protein network of inhibitory synapses.