As I said in my previous post, I’ve been selected to create all 12 of The Lancet Oncology’s conceptual cover images for 2024. Here is the first one!
The manuscript the image is based on compares two different therapeutic approaches in the treatment of locally advanced or metastatic urothelial carcinoma. The central element in the image is a gnarled and menacing-looking tree with branches representing the paths of metastases/invasive cancer spread. The leaves are loosely representative of urothelial carcinoma cells and reference invasive urothelial cancer histology. The droplets (representing therapeutic drug infusion) carry both monoclonal antibody and a platinum-based chemotherapy molecule (I chose Cisplatin as the molecule). On the bottom left and mid-right, monoclonal antibody molecules (violet) are shown binding to PD-L1 receptor molecules (blue) embedded in the cell membrane of a urothelial cancer cell.
I’ve already completed the art for the February and March editions of The Lancet Oncology. I’ll be sharing the next cover as soon as the February issue is released!
